The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-κB-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation

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The involvement of follistatin-like protein 1 in osteoarthritis by elevating NF-κB-mediated inflammatory cytokines and enhancing fibroblast like synoviocyte proliferation

INTRODUCTION Our previous work has revealed that expression of follistatin-like protein 1 (FSTL1) is elevated in the synovial tissues from osteoarthritis (OA) patients. The aim of this study was to elucidate the underlying molecular mechanisms by which FSTL1 plays a role in the pathogenesis of OA. METHODS Cultured fibroblast-like synoviocytes (FLSs) from synovial tissues of OA patients were s...

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ژورنال

عنوان ژورنال: Arthritis Research & Therapy

سال: 2015

ISSN: 1478-6354

DOI: 10.1186/s13075-015-0605-6